Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance.

 Excessive estradiol secretion in polycystic ovarian disease.

Podcast explaining the connection between excess estrogen, metabolic issues, PMS, PCOS, endometriosis and breast cancer from a biochemistry, metabolic and energetic perspective

Collection of quotes from one of my favorite biochemists/biologists Ray Peat, Phd talking about estrogen and PCOS with cited sources:

 An excerpt from Ray Peat’s Article:

"One injection of estrogen can induce a large increase in the number of sympathetic nerves in the ovaries. At menopause, a similar “invasion” of sympathetic nerves occurs. The polycystic ovary (which is even more common after menopause than before, and some studies have found the condition in 20% of premenopausal women) responds to estrogen by producing nerve growth factor(s), and growing a large number of new sympathetic nerves. Although the hyperestrogenism associated with the polycystic ovary syndrome has many harmful effects, the invasion of the ovary by adrenergic nerves apparently protects it from the development of cancer.

Parasympathetic nerves, pituitary hormones and mast cells activate the ovaries. The number of mast cells in the ovaries is increased by the pituitary hormones (including the thyroid stimulating hormone), and by estrogen (Jaiswal and Krishna, 1996). Estrogen is the most potent of these hormones in causing the cells to release histamine. The overgrowth of the sympathetic nerves in the polycystic ovary causes the number and activity of mast cells to decrease, possibly as a protective adaptation against excessive stimulation from the many pro-inflammatory factors. The mast cells are needed for the follicles to rupture, so their suppression prevents ovulation."

Read the rest of the article here:

 On demonization of sugar (each article has multiple sources)::

 Why the type of fat you eat determines how you burn sugar (article has multiple sources):

 Thyroid info (article has multiple sources): :